Sustain Alpha Reviews

[O.N.]

Ok i haven't tried it yet.
But I am very interested in the science.
So I am going to copy and paste all the info i can find on each of the scientific claims and you can see for yourself if it sounds any good.

So here are the science claims: (i will use google to find each one)
References -

1. Resveratrol in Cardioprotection: A Therapeutic Promise of Alternative Medicine
Dipak K. Das et al.
Mol. Interv., Feb 2006; 6: 36 - 47.


2. The Red Wine Polyphenol Resveratrol Displays Bilevel Inhibition on Aromatase in Breast Cancer Cells
Yun Wang, et al.
Toxicol. Sci., Jul 2006; 92: 71 - 77.

3. trans-Resveratrol, a Natural Antioxidant from Grapes, Increases Sperm Output in Healthy Rats M. EmÃ*lia Juan, et al.
J. Nutr., Apr 2005; 135: 757 - 760

4. trans-Resveratrol relaxes the corpus cavernosum ex vivo and enhances testosterone levels and sperm quality in vivo.
S Shin, et al.
Arch Pharm Res, Jan 2008; 31(1): 83-7.

5. Inhibition of human estrogen synthetase (aromatase) by flavones
JT Kellis, Jr et al.
Science, Sep 1984; 225: 1032 - 1034.

6. Drug/substance reversal effects of a novel trisubstituted benzoflavone moiety (BZF) isolated from Passiflora incarnata Linn. - a brief perspective
KAMALDEEP DHAWAN et al.
Addiction Biology (December 2003) 8, 379 - 386

7. Prevention of chronic alcohol and nicotine-induced azospermia, sterility and decreased libido, by a novel tri-substituted benzoflavone moiety from Passiflora incarnata Linneaus in healthy male rats.
K Dhawan and et al.
Life Sci, Nov 2002; 71(26): 3059-69.

8. Molecular basis of the inhibition of human aromatase (estrogen synthetase) by flavone and isoflavone phytoestrogens: A site-directed mutagenesis study.
Kao YC, et al.
Environ Health Perspect 1998;106:85-92

9. Vasorelaxant and antioxidant activity of flavonols and flavones: structure-activity relationships.
OL Woodman, WF Meeker, and M Boujaoude
J Cardiovasc Pharmacol, Sep 2005; 46(3): 302-9.

10. Die Bedeutung der Passionsblume in der Heilkunde.
Lutomski J et al.
Pharmazie in unserer Zeit 1981;10:45-49.

11. The Honest Herbal: A Sensible Guide to the Use of Herbs and Related Remedies.
Tyler VE et al.
Pharmaceutical Products Press, New York, 1993.

12. Aphrodisiac activity of methanol extract of leaves of Passiflora incarnata Linn in mice.
K Dhawan, et al.
Phytother Res, Apr 2003; 17(4): 401-3.

13. Preoperative Oral Passiflora Incarnata Reduces Anxiety in Ambulatory Surgery Patients: A Double-Blind, Placebo-Controlled Study
Ali Movafegh, et al.
Anesth. Analg., Jun 2008; 106: 1728 - 1732.

14. Essential oils are novel human skin penetration enhancers.
Williams A, et al.
Int J Pharmaceuticals 57:R7-R9, 1989

15. Allyl-containing sulfides in garlic increase uncoupling protein content in brown adipose tissue, and noradrenaline and adrenaline secretion in rats.
Oi, Y. et al
J. Nutr. 129: 336-342. (1999)

16. Garlic Supplementation Increases Testicular Testosterone and Decreases Plasma Corticosterone in Rats Fed a High Protein Diet
Yuriko Oi, et al.
J. Nutr., Aug 2001; 131: 2150 - 2156.

17. Corticosterone Can Act at the Posterior Paraventricular Thalamus to Inhibit Hypothalamic-Pituitary-Adrenal Activity in Animals that Habituate to Repeated Stress
Azra Jaferi et al.
Endocrinology, Oct 2006; 147: 4917 - 4930

18. Study of the effect of sclareol glycol diterpene on the release of adenohypophysial hormones prolactin, somatotropin and adenocorticotrophic hormone
Georgieva et al.
Eksp Med Morfol. 1989;28(3):7-14. Bulgarian.

19. Study of the effect of sclareol glycol diterpene on the 3',5'-AMP level
Georgieva et al.
Eksp Med Morfol. 1989;28(3):1-7. Bulgarian.

20. Understanding True Aromatherapy: Understanding Essential Oils
Eileen D, et al.
Home Health Care Management Practice, Oct 2004; 16: 474 - 479.

21. Neuroactive flavonoids interacting with GABAA receptor complex.
F Wang, M Shing, Y Huen, SY Tsang, and H Xue
Curr Drug Targets CNS Neurol Disord, Oct 2005; 4(5): 575-85.

22. Prevention of chronic alcohol and nicotine-induced azospermia, sterility and decreased libido, by a novel tri-substituted benzoflavone moiety from Passiflora incarnata Linneaus in healthy male rats.
K Dhawan and et al.
Life Sci, Nov 2002; 71(26): 3059-69.

23. Passiflora: a review update.
Dhawan K, Dhawan S, Sharma A.
J Ethnopharmacol. 2004 Sep;94(1):1-23. Review.

24. A gamma-aminobutyric acidB agonist reverses the negative feedback effect of testosterone on gonadotropin-releasing hormone and luteinizing hormone secretion in the male sheep.
Endocrinology. 2000 Nov;141(11):3940-5.

25. Drug/substance reversal effects of a novel tri-substituted benzoflavone moiety (BZF) isolated from Passiflora incarnata Linn. – a brief perspective.
Dhawan, et al.
Addiction Biology 379-386

26. Anticonvulsant effects of aerial parts of Passiflora incarnata extract in mice: involvement of benzodiazepine and opioid receptors.
Nassiri-Asl M, Shariati-Rad S, Zamansoltani F.
BMC Complement Altern Med. 2007 Aug 8;7:26.

27. Effects of Dialyzing γ-Aminobutyric Acid Receptor Antagonists into the Medial Preoptic and Arcuate Ventromedial Region on Lutienizing Hormone Release in Male Sheep.
Suzie A, et al.
Biology of Reproduction 58, 1038-1046 (1998)

28. Antiandrogen Microimplants into the Rostal Medial Preoptic Are Decrease γ-Aminobutyric Acidergic Neuronal Activity and Increase Luteinizing Hormone Secretion in the Intact Male Rat.
David R et al.
Endocrinology, Vol. 137 No. 10 (1996)

29. Non-classical estrogen modulation of presynaptic GABA terminals modulates calcium dynamics in gonadotropin-releasing hormone (GnRH) neurons.
Nicola Romano, et al.
Endocrinology, 10.1210/en.2008-0424 (2008)

30. Restoration of the Luteinizing Hormone Surge in Middle-Aged Female Rats by Altering the Balance of GABA and Glutamate Transmission in the Medial Preoptic Area
Genevieve S, et al.
Biol Reprod, Jul 2008; 10.1095/biolreprod.108.069831.

[O.N.]

[1]
Resveratrol, a polyphenol phytoalexin, possesses diverse biochemical and physiological actions, including estrogenic, antiplatelet, and anti-inflammatory properties. Several recent studies determined the cardioprotective abilities of resveratrol. Both in experiments (acute) and in chronic models, resveratrol attenuates myocardial ischemic reperfusion injury, atherosclerosis, and reduces ventricular arrhythmias. It appears that resveratrol-mediated cardioprotection is achieved through the preconditioning effect (the best yet devised method of cardioprotection), rather than direct protection. Thus, resveratrol likely fulfills the definition of a pharmacological preconditioning compound and gives hope to the therapeutic promise of alternative medicine.
http://www.ncbi.nlm.nih.gov/pubmed/16507749

[2]
Estrogen plays a crucial role in the development of breast cancer, and the inhibition of estrogen synthesis has been an important target for the prevention and treatment of this disease. The rate-limiting reaction of the hormone biosynthesis is catalyzed by cytochrome P450 (CYP) 19 enzyme or aromatase. It has been of genuine interest to uncover an aromatase-inhibitory compound from a dietary source. Resveratrol is a polyphenolic compound that can be isolated from grape peel. Because of its structural resemblance to estrogen, resveratrol's agonistic and antagonistic properties on estrogen receptor have been examined and demonstrated. In the present study, the effect of resveratrol on the expression and enzyme activity of aromatase was investigated. By assaying on MCF-7 cells stably transfected with CYP19 (MCF-7aro cells), resveratrol inhibited the aromatase activity with an IC50 value of 25µM. Kinetic analysis indicated that both competitive and noncompetitive inhibition might be involved. The administration of 10 nmol/l testosterone—a substrate of aromatase—produced a 50% increase in the MCF-7aro cell number. This cell proliferation specifically induced by testosterone was significantly reduced by 10µM resveratrol. In addition, 50µM resveratrol significantly reduced the CYP19-encoding mRNA abundance in SK-BR-3 cells. The transcriptional control of CYP19 gene is tissue specific, and promoter regions I.3 and II have previously been shown to be responsible for CYP19 expression in breast cancer cells. Luciferase reporter gene assays revealed that resveratrol could repress the transcriptional control dictated by the promoter regulation. The present study illustrated that pharmacological dosage of resveratrol inhibited aromatase at both the enzyme and mRNA levels.
http://toxsci.oxfordjournals.org/cgi...stract/92/1/71

[3]
trans-Resveratrol was reported to have health benefits including anticarcinogenic effects and protection against cardiovascular disease. One of the mechanisms by which it exerts its action is through modulating the estrogen response systems. Because estrogen is involved in male reproductive biology, we investigated the effect of trans-resveratrol on testis and spermatogenesis. Adult male rats were divided into 2 groups. The treated group was administered by gavage 20 mg/(kg · d) of trans-resveratrol suspended in 10 g/L of carboxymethylcellulose for 90 d, whereas the control group received only carboxymethylcellulose during the same period. The relative weight of testes did not differ between the groups. However, the diameter of the seminiferous tubules was significantly reduced from 437.5 ± 0.1 µm in the controls to 310.9 ± 0.1 µm in the resveratrol–treated rats. This decrease was accompanied by a significant increase in tubular density, from 3.20 ± 0.18 in controls to 6.58 ± 0.18 tubules/mm2 in the treated group. Moreover, sperm counts were significantly greater in the resveratrol-treated rats (24.8 ± 3.30 x 107) than in the control group (14.1 ± 0.80 x 107), but sperm quality did not differ. Serum concentrations of gonadotrophins and testosterone were significantly higher in the resveratrol-treated group. We identified a novel activity of trans-resveratrol. The daily oral administration of this phytochemical to adult male rats enhanced sperm production by stimulating the hypothalamic-pituitary-gonadal axis, without inducing adverse effects.
http://jn.nutrition.org/cgi/content/full/135/4/757 (FULL MED JOURNAL)

[4]
We examined the effects of trans-resveratrol on male reproductive functions; ex-vivo penile erection and in-vivo sperm counts and quality. For the ex-vivo study, the relaxation effects of resveratrol on isolated New Zealand white rabbit corpus cavernosum, precontracted by phenylephrine (5x10(-5) M) were measured. The in-vivo study measured reproductive organ weights, blood testosterone levels, testicular histopathology, sperm counts, as well as the epididymal sperm motility and deformity of male ICR mice given an oral dose of resveratrol (50 mg/ kg) for 28 days. Resveratrol elicited a concentration-dependent relaxing effect on corpus cavernosum, leading to a median effective concentration (EC50) of 0.29 mg/mL. Repeated treatment with resveratrol (50 mg/kg) did not cause an increase in body weight, reproductive organ weight or testicular microscopic findings; however, resveratrol did elicit an increase in blood testosterone concentration, testicular sperm counts and epididymal sperm motility by 51.6%, 15.8% and 23.3%, respectively, without influence on sperm deformity. In conclusion, we propose that resveratrol has a positive effect on male reproductive function by triggering a penile erection, as well as enhancing blood testosterone levels, testicular sperm counts, and epididymal sperm motility.
https://www.researchgate.net/publica...uality_in_vivo

[5]
Several naturally occurring and synthetic flavones were found to inhibit the aromatization of androstenedione and testosterone to estrogens catalyzed by human placental and ovarian microsomes. These flavones include (in order of decreasing potency) 7,8-benzoflavone, chrysin, apigenin, flavone, flavanone, and quercetin; 5,6-benzoflavone was not inhibitory. 7,8-Benzoflavone and chrysin were potent competitive inhibitors and induced spectral changes in the aromatase cytochrome P-450 indicative of substrate displacement. Flavones may thus compete with steroids in their interaction with certain monooxygenases and thereby alter steroid hormone metabolism.
http://www.ncbi.nlm.nih.gov/pubmed/6474163

[6]
The present work is a mini-review of the author's original work on the plant Passiflora incarnata Linn., which is used in several parts of the world as a traditional medicine for the management of anxiety, insomnia, epilepsy and morphine addiction. A tri-substituted benzoflavone moiety (BZF) has been isolated from the bioactive methanol extract of this plant, which has been proposed in the author's earlier work to be responsible for the biological activities of this plant. The BZF moiety has exhibited significantly encouraging results in the reversal of tolerance and dependence of several addiction-prone psychotropic drugs, including morphine, nicotine, ethanol, diazepam and delta-9-tetrahydrocannabinol, during earlier pharmacological studies conducted by the author. In addition to this, the BZF moiety has exhibited aphrodisiac, libido-enhancing and virility-enhancing properties in 2-year-old male rats. When administered concomitantly with nicotine, ethanol and delta-9-tetrahydrocannabinol for 30 days in male rats, the BZF also prevented the drug-induced decline in sexuality in male rats. Because the BZF moiety isolated from P. incarnata is a tri-substituted derivative of alpha-naphthoflavone (7,8-benzoflavone), a well-known aromatase-enzyme inhibitor, the mode of action of BZF has been postulated to be a neurosteroidal mechanism vide in which the BZF moiety prevents the metabolic degradation of testosterone and upregulates blood-testosterone levels in the body. As several flavonoids (e.g. chrysin, apigenin) and other phytoconstituents also possess aromatase-inhibiting properties, and the IC50 value of such phytomoieties is the main factor determining their biochemical efficacy, by altering their chemical structures to attain a desirable IC50 value new insights in medical therapeutics can be attained, keeping in view the menace of drug abuse worldwide.
http://cat.inist.fr/?aModele=afficheN&cpsidt=15384743

[7]
Excessive long term consumption of alcohol and nicotine have serious detrimental effects upon the libido, fertility, and sperm count in male species. The present work describes the beneficial effects of a novel tri-substituted benzoflavone moiety (BZF) isolated from Passiflora incarnata Linneaus, the phyto-chemical isolation, spectroscopic elucidation, and multifarious biological activities of which have recently been reported by the authors. The BZF moiety has been reported to increase libido, sperm count, and sexual fertility in 2 years old male rats at 10 mg/kg, po dose, in the one of our previous studies. Presently, the BZF moiety has been evaluated against chronic ethanol- and nicotine-induced decrease in libido, sexual fertility and mating efficiency in healthy male rats. The male rats were given ethanol (3 g/kg, po) A , nicotine (2 mg/kg, sc) N, alcohol-nicotine combinations (AN) alone, and also with 10 mg/kg po dose of BZF (concurrent administrations). These treatments were given for 30 days. At the end of treatments, it was observed that rat groups A, N, and AN had no libido (evaluated by mounting behaviour), declined sperm count, and consequently no mating efficiency or fertility (upon pairing with pro-estrus female rats). However, the rats which were given 10 mg/kg BZF along-with nicotine (NP group), alcohol (AP group), and alcohol-nicotine combination (ANP) exhibited significant libido-oriented mounting behaviour, increased sperm count (significantly comparable to the control group), and increased fertilization potential. The rats having decreased sperm count, libido and fertilization potential due to chronic administration of alcohol, nicotine and alcohol-nicotine combinations, i.e., rats of A, N, and AN groups were again subdivided and were given 10 mg/kg BZF for 7 days. This treatment confirmed that BZF speeds up the restoration of sexuality in rats upon cessation of the administration of substances like alcohol, nicotine and alcohol-nicotine combinations, which have severe detrimental effects upon male sexuality, fertility and vigour. BZF, the strongest inhibitor of aromatase enzyme, when administered concurrently with substances like alcohol and nicotine restores sexual virility, libido and vigour in male rats by maintaining the blood-testosterone levels to be high.
http://www.sciencedirect.com/science...0c5e0f5a1be8f4

[8]
Flavone and isoflavone phytoestrogens are plant chemicals and are known to be competitive inhibitors of cytochrome P450 aromatase with respect to the androgen substrate. Aromatase is the enzyme that converts androgen to estrogen; therefore, these plant chemicals are thought to be capable of modifying the estrogen level in women. In this study, the inhibition profiles of four flavones [chrysin (5, 7-dihydroxyflavone), 7,8-dihydroxyflavone, baicalein (5,6,7-trihydroxyflavone), and galangin (3,5,7-trihydroxyflavone)], two isoflavones [genistein (4,5,7-trihydroxyisoflavone) and biochanin A (5,7-dihydroxy-4-methoxyisoflavone)], one flavanone [naringenin (4, 5,7-trihydroxyflavanone)], and one naphthoflavone (alpha-naphthoflavone) on the wild-type and six human aromatase mutants (I133Y, P308F, D309A, T310S, I395F, and I474Y) were determined. In combination with computer modeling, the binding characteristics and the structure requirement for flavone and isoflavone phytoestrogens to inhibit human aromatase were obtained. These compounds were found to bind to the active site of aromatase in an orientation in which rings A and C mimic rings D and C of the androgen substrate, respectively. This study also provides a molecular basis as to why isoflavones are significantly poorer inhibitors of aromatase than flavones.
http://www.pubmedcentral.nih.gov/art...?artid=1533021

[9]
We investigated the structure-activity relationships regarding vascular and antioxidant activity of a range of synthetic flavonols and flavones with 3 or fewer hydroxyl (OH) or methoxyl substitutions. The relaxant responses and ability of the flavones/flavonols to inhibit phenylephrine (PE)- and Ca-induced contraction was determined in rat isolated thoracic aorta. The ability of these compounds to reduce the level of superoxide and preserve endothelium-dependent relaxation in the presence of oxidative stress was also examined. Four compounds impaired contraction to PE or Ca, in the potency order 3'-hydroxyflavonol>3',4'-dihydroxyflavonol>7,4'-dihydroxyflavonol>3',4'-dihydroxyflavone. Flavonol, 3',4'-dimethoxyflavonol, and flavone were significantly less active. The flavonoids caused concentration-dependent reductions in superoxide produced by rat aorta in the presence of NADPH. The most active compounds, 3',4'-dihydroxyflavonol and 7,4'-dihydroxyflavonol, preserved endothelium-dependent relaxation in the presence of oxidative stress caused by pyrogallol or xanthine/xanthine oxidase. The results indicate that the catechol group is not critical for vascular relaxant or antioxidant activity, but rather, the important determinants for higher vascular and antioxidant activity of these compounds are the presence of a C3 OH group and the total number of OH substituents, respectively. These results have allowed the identification of the structural characteristics that promote vascular and antioxidant activity of flavonols, which may lead to the development of agents useful in treatment of cardiovascular disease.
http://www.ncbi.nlm.nih.gov/pubmed/16116335

[10]
In another language cant underdstand it.

[O.N.]

Blood Test Results:

I had come off of a cycle end of november and ran PCT - post cycle therapy - of hcg, HMG and Clomid and end of January got blood results -- everything was low: 96 for serum test, FH =1.2, lh - leutenizing hormone - =0.4
I went on Sustain alpha and post cycle and Unleashed and just had another blood test end of February:
serum test = 318
lh - leutenizing hormone - =4.4
and FSH - follicle stimulating hormone - = 4.2
!! im pretty happy with the products !!
thanks!!!! http://www.elitefitness.com/forum/an...ht-586470.html

As promised I am posting my blood test results after running nolva and PP's Test Recovery Stack for PCT - post cycle therapy - after what was a fairly heavy cycle. I must say I am impressed. My Test levels almost a month after finishing PCT - post cycle therapy - are at 635 ng/dL. This is compared to 315 ng/dL in March this year after an earlier cycle. I have not seen my test levels this high for some years in fact.

It seems very clear to me that the Test Recovery Stack pla a very large part in elevating my serum test levels. I also ran nolva in PCT - post cycle therapy - and hcg on cycle. I know many guys advocate different ways to do PCT - post cycle therapy - but for me this works and works exceptionally well and I will continue this same protocol now and should help me avoid having at some time in the future to do HRT.http://www.elitefitness.com/forum/an...-594158-5.html

Reviews:

In short, I've been applying for the past week @ 4 pumps per day after my morning shower. I have had what I would call chronic libido issues for the past year, ever since coming off of Havoc. In fact, I was making an appointment to see the doc for a referral to the endocrinologist to get this shit straightened out and then I figured I'd try the Sustain Alpha first.

Within 2 days I had noticeably improved libido. I'm talking better than any time in the past year. Morning wood, check. Random daytime wood, check. Full stock whenever I want, check. Sweet.

It has been a week now and I'm kind of left wondering why I wanted my libido back so badly. It's getting annoying. I feel like I'm 21 again, with a compulsive desire to thrust into things at any opportunity.

Pros:
Super libido boost
Rad boners
Definite improved sense of well-being, alpha male-ness feeling
Pleasant smell (and the only topical I've used consistently for more than 2 days due to this fact)
Good moisturizing type lotion, non-staining (so far)

Cons:
Palm chafe
Reduced sleep quality due to frequent erections (apparently it IS possible to cockblock yourself in dreams)
Seriously though - none that I can see at this time.

I'll definitely be taking you up on your generous coupon offer that you included with the sample. Do you guys sell this in liters?
http://www.mindandmuscle.net/forum/i...howtopic=35474

I am very impressed with Sustain. My libido in general is down as long as Im not on test. But this week using Sustain and ZMA, my libido has been thru the roof. I have started masturbating again which is no small feat for married man of 32.

This stuff is great. Best libido booster I have ever tried period.http://www.mindandmuscle.net/forum/i...dpost&p=509240

For fu*ks sake, I have not had morning wood in so damn long.....This Sustain shit is awesome!!!!

In the 3 days since I got my sample, I have nutted no less than a dozen times. I actually ran a batch on the interstate in my work truck!!! I have not felt this sexually excited since high school.

My balls are finally bigger than a 9year olds too, which is a plus.

PP, you have earned yourself a lifetime customer, as long as this shit doesn't kill me.http://www.mindandmuscle.net/forum/i...howtopic=35412

Sustain is def no joke. I have been using it 2 hours pre-sex to makes things more interesting. The smell and the libido boost is right on....I am using P6 red at the moment so the Sustain for now is just icing on the cake, but when i used it straight up for 2 weeks PCT it took clomid to another level http://www.mindandmuscle.net/forum/i...dpost&p=507957

So far this stuff seems to be working. My libido is definitely up. I was with my ex last night and had some really good sex. I was high which always makes it better but this time the sensitivity in that area was greater which is awesome because after doing an epi/pp cycle over a year ago things just never seemed to be back to normal after that. Last night made me feel like i was 18 again hopefully this keeps up http://www.mindandmuscle.net/forum/i...dpost&p=508965

[O.N.]

resveratol 60 minutes

[C_T]

I don't believe anything that comes from elitefitness.com

That place is preying on bodybuilders spending cash on supplements.

[micksnowdog]

i patially agree with the above statement, i do believe in and use the trs myself tho.

[UN Soldier]

thats so much reading mate, brb.

[crreaby]

Hey ON,
when do you expect to stock SustainAlpha Liqua Vade?
any ideas on the price you will sell it for?

thanks

[O.N.]

Hey ON,
when do you expect to stock SustainAlpha Liqua Vade?
any ideas on the price you will sell it for?

thanks

it will be the same price as the cream and it will be soon, just trying to clear some stock first.

[crreaby]

it will be the same price as the cream and it will be soon, just trying to clear some stock first.

do i hear a sale? lol

[O.N.]

do i hear a sale? lol

more so me being lazy, i'll order soon dont worry i want some too.

[crreaby]

more so me being lazy, i'll order soon dont worry i want some too.

good to hear! ... it seems much more convenient than rubbing yourself:P
and i read some where, the oral version is more bio-availible, if thats the right word!